Guardiola knows Tottenham will pose a serious threat to City's quadruple dreams over the next few days, and he called on the Etihad crowd to produce an intimidating atmosphere.
With City now in front of their own people, Guardiola is looking for them to have an impact and guide the Premier League champions into the last four of the competition.
Harry Winks is another Tottenham player who could miss out, but City have concerns over Fernandinho, who didn't feature in the 3-1 win at Crystal Palace last weekend.
Pochettino agrees that Pep Guardiola's formidable squad are worthy of the favourites' tag. And both these sides are more than capable of causing an upset.
"As soon as I got back to my parents' house, I walked in the door and could see that my mother was crying", he said. "I've had this feeling for weeks", Guardiola said. But I think we stayed in the match very well today. They'll need to be on top of their game tonight if they are to advance to the semifinals for only the second time.
"It will be an awesome challenge". Their midweek opponents Ajax played a strong side as they hammered Excelsior 6-2 in a vital game in the Eredivisie title race. "At 8 o'clock tomorrow it will be a battle".
"That is the reality and it happened to many, many teams with many, many situations, but we have another option and another chance and that is the point". They'll need the likes of Son Heung-Min and Lucas Moura to step up and fill that scoring void.
"At the end of the year, I packed my bags and said goodbye to my foster family". We met in Spain when we played and managed.
"We have got five games left in the league, everything to play for and we've got to keep believing and enjoying the pressure".
Capped 68 times by the Red Devils, De Bruyne said he was taken aback by what was happening in the manager's office. So I thought maybe Chelsea would let me go'. He is the most successful manager in the last 10 years for sure.
A win would move City back into first place on 86 points from 34 games. "What he is doing is unbelievable".
This would also effectively be City's game in hand.
Donny van de Beek has admitted his perference for a semi-final meeting with Tottenham Hotspur in the Champions League as Spurs have former Ajax players in their ranks. We did it in a really good manner.
"Why not? The players need to listen to that".
To put this into perspective, no other side in Europe who are featuring in the quarter-finals of the Champions League played on Sunday. The defending Premier League champions have been at their scintillating best at the Etihad Stadium.
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